A couple of years ago, I was modding a fresh install of Skyrim and thought, "I can use git branches to make it easy to switch between different mod combinations rather than uninstalling/reinstalling mods when something breaks or when I want to change things up." Worked well!
I had branches that were mostly vanilla with enhancements, and then branches that had all kinds of ridiculous mods. If I wanted to switch to playing a ridiculous build of Skyrim, I'd just close the game, checkout the branch I wanted, and start the game.