Firefox

If you click on uBOs icon up in the upper right of the browser, you can of course disable uBO on that page, but there are other options contained therein. On the same popup for disabling on a page is a little gear for settings. If you click that and go to something like built in filters or something (not at my computer), you'll see a list of filters, maintained by other individuals, categorized by taste and targeted annoyance. You can check additional lists to use them based on what they do.

As long as you leave auto update lists on, you only really need to occasionally reload a page. However, if you turn off auto update you may start to see YouTube ads or warnings about ad blockers until you update the lists manually. To update the lists manually, click the little clock icon next to the list. If it's green, it recently updated, if it's grey, then it could use ah update or a check for updates.