this post was submitted on 06 Jan 2024
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A gel injected into the scrotum could be the next male contraceptive::Biotech company Contraline has safely implanted a sperm-blocking hydrogel in 23 men. It’s designed to be a fully reversible vasectomy.

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[–] [email protected] 97 points 10 months ago (17 children)

This kind of thing pops up repeatedly. There's some big, splashy news about a male contraceptive, and then it flames out, or ends up being vaporware.

The problem is that you need to stop a few million sperm with every single ejaculation; reducing that number by 99% means that you're still risking pregnancy. Severing the ductus deferens (a vasectomy) means no sperm get through; trying to clip or block them means that some can potentially get through. Hormonal BC has the same issue; while it significantly reduces sperm count, it may not eliminate it entirely. (And there can be some really significant negative side effects from eliminating endogenous testosterone production, since hormonal levels need to be pretty far out of whack before there's a really big cut in sperm production.)

OTOH, women have to stop two eggs per month, or stop them from being implanted in the uterine wall. A 99% reduction in fertility for women means that it's very, very unlikely that they're going to be able to get pregnant.

(Yes, women suffer from hormonal BC as well, but some women need it just to be able to live normal lives. It's overall less of a problem than it ends up being for men. And women have the option of an IUD as well.)

Personally, I'm in favor of vasectomy; it's allowed me to avoid having any children for 20-odd years now.

[–] [email protected] 31 points 10 months ago (1 children)

Ive also avoided making kids for the last decade or so but I was born with personality-based contraceptives so I dont know that it counts

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[–] [email protected] 10 points 10 months ago (1 children)

The problem I've read with Vasalgel is that they had trouble getting enough voulenteers to test it. Trials are dragging out. It does appear to work otherwise.

I was holding out on it for a while, but ended up getting a vasectomy.

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[–] [email protected] 10 points 10 months ago (2 children)

You are comparing sperm count and egg count as if the amount it an issue. For eggs not to be released, you end up nuking estrogen production. Hormonal BC for women is a lesser evil when comparing it to unwanted pregnancies and health conditions like endo, but you are underestimating just how bad constantly taking the pill for women is.Vasectomy is the way.

[–] [email protected] 13 points 10 months ago

Vesectomy is the way if you know for sure that you never want children - they aren’t reversible like birth control are and shouldn’t really be considered reversible at all because there’s a very real risk of them not being so

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[–] [email protected] 78 points 10 months ago* (last edited 10 months ago) (2 children)

Vaselgel is too cheap to manufacture to get the funding it needs to bring it to market, that's why they have been trying for 20 years and haven't succeeded yet. In the US the rights are owned by a non profit Parsemu Foundation formed to fund it. It looks like their private partner NEXT Life Sciences is actually set to come to market with a vaselgel product in 2026 they are calling Plan A.

https://www.prnewswire.com/news-releases/next-life-sciences-announces-launch-of-plan-a-birth-control-for-men-301779007.html

Interesting marketing choice comparing it to the Plan B pill.

[–] [email protected] 27 points 10 months ago (2 children)

If Plan A works, you don't need Plan B... 😄

[–] [email protected] 11 points 10 months ago

I think that was always the point of the name. this would just be a new plan A.

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[–] [email protected] 9 points 10 months ago

From what I'm reading, they're not set to go to market; that's just their goal. Most recent article I found was middle of last year that they had raised more money and were hoping to go to human trials by the end of the year. That aligns with what I remember about Vasalgel from years ago - they had finally made it to monkey trials but their monkey study was not showing a consistent ability to return to virility with the second injection. I seem to remember the proposed reason being that vas deferens in the monkeys/apes they were testing with are actually more delicate than humans' and so humans should still likely be reversible. Last I heard, I believe they were trying to move forward on the human trial of proving that it works as a contraceptive, to be followed by a human trial showing reversibility. Then radio silence and funding issues. My assumption has always been that they struggled to jump to human trials because of the primate study results hurting the likelihood of reversibility. Hopefully they have reworked it to solve that, or maybe the acquisition and new funding is enough to just push through that regardless and see if humans will be fine.

[–] [email protected] 49 points 10 months ago (1 children)
[–] [email protected] 42 points 10 months ago (8 children)

A vasectomy in my twenties was the best decision I ever made.

10/10, would snip, tie and burn again.

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[–] [email protected] 31 points 10 months ago (2 children)

I gave up on waiting for this tech to become available and just got a vasectomy.

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[–] [email protected] 27 points 10 months ago (3 children)

They are going to need to work on their sales pitch...

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[–] [email protected] 21 points 10 months ago (2 children)

It looks promising, even though it is quite far away from becoming available to the general public.

Still I wish that there was more of a push for something like a contraceptive pill for men. It feels like it has been ignored for years and only now they are starting a bit with development and trials...

[–] [email protected] 41 points 10 months ago* (last edited 10 months ago) (1 children)

I don't think it's been ignored. Birth control pills for men would be a massive money maker. (Here is a recent article I found on BC for men: https://www.nih.gov/news-events/nih-research-matters/male-contraceptive-disables-sperm)

While I am speaking way outside my confort zone here, it seems magnitudes harder to effectively disable millions of sperm and their associated production as opposed to simply knocking a woman's hormone balance a little out of whack to prevent ovulation.

The bigger question is being ignored though: If we have to inject our scrotum with a gel, where are we going to store our pee?????

[–] [email protected] 18 points 10 months ago

We'll just have to pee out of our butts like girls do.

[–] [email protected] 13 points 10 months ago (2 children)

Unfortunately there has to be almost no side effects for almost all users, as there are no (as yet) medical benefits to male contraception.

In women, not being pregnant can prevent death for some of them, regulate painful periods, etc. - it is considered the risk of the myriad side effects is worth it because at least it does some good.

For men, who do not become pregnant, not being able to get someone else pregnant is not a medical benefit for the man.

And unfortunately hormonal modification does cause problems. Lots of them.

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[–] [email protected] 19 points 10 months ago (1 children)

These reversable, injectable, male contraceptives have been promised for at least 5 years, when will they come to market?

[–] [email protected] 8 points 10 months ago* (last edited 10 months ago)
[–] [email protected] 18 points 10 months ago (8 children)

More options are great I suppose, but as a gem-xer I don't get the modern revolt against the condom. Modern condoms are pretty damn thin / good and are a form of male birth control with bonus of very good disease prevention, have next to no side effects, and minimize messes too.

[–] [email protected] 34 points 10 months ago (4 children)

All true, but they also feel awful, sometimes painfully tight, and are total erection killers. I use them, but I hate using them.

[–] [email protected] 10 points 10 months ago

It's the pause in the flow of things to go get one and put it on plus difficulty finding the right size. Used em my entire life until my wife had an IUD put in. After a few ears she had it removed and going back to condoms was not super fun for either of us.

On the bright side for me, a vasectomy solved all these issues and was totally worth the minimal process to get it. This solution sounds like a dream honestly.

[–] [email protected] 8 points 10 months ago (1 children)

Feeling awful is true (or having less feeling overall), but you can just buy a bigger size if it's too tight. The run of the mill condoms are uncomfortable for me too, look at something like https://www.my-size-condoms.com/

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[–] [email protected] 18 points 10 months ago (1 children)

Modern?

Has it increased in some way over time? I think men not wanting to wear condoms because of how they feel is a tale as old as the condom itself.

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[–] [email protected] 5 points 10 months ago (1 children)

IMO for anyone in a stable monoamorous relationship, the IUD is the superior option, as long as the female partner is a good fit for it and doesn't have complications from it.

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[–] [email protected] 17 points 10 months ago

This isn't exactly new. Vasalgel offers a similar injection that blocks the tubes, however before then back in the early 2010's there was also a guy in India testing a better version which did not block the tubes - the compound was polarised, and when the sperm went through it was disoriented such that it couldn't swim to the egg. The human clinical trials had a 100% success rate at preventing pregnancy, albeit human trials tend not to have that many people (I think there were 26). My understanding is that this became Vasalgel because the pharmacuetical industry didn't like the fact that it completely avoided the complications that can come with vasectomies where the tube is completely blocked.

[–] [email protected] 17 points 10 months ago (2 children)

I've been seeing promises about a new male contraceptive for more than a decade now. They never seem to hit the shelves form some reason.

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[–] [email protected] 13 points 10 months ago (1 children)

This turns the scrotum into a stress ball.

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[–] [email protected] 11 points 10 months ago (1 children)

RISUG has been in promised for what, nearly a decade now? This has been the FSD/Star Citizen of the male contraceptive world, always right around the corner.

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[–] [email protected] 10 points 10 months ago* (last edited 10 months ago) (1 children)

Is this not the exact same thing as vasalgel? How is this new or different?

[–] [email protected] 6 points 10 months ago

Not sure, this seems to be exactly what vasalgel is. At first, I thought the innovation was that they just squirt this stuff into your sack and call it a day, and that would have been different. But nope! Same injection site too. Maybe it's more effective or something.

[–] [email protected] 9 points 10 months ago

Been trying this for 2 decades

[–] [email protected] 8 points 10 months ago

Contraline’s method involves making a small piercing in the scrotum and using a handheld injector to push the hydrogel through a catheter that’s connected to the vas deferens. The catheter is then taken out, and the puncture heals on its own.

That sounds like a bit more than just an injection. Not quite like going in for a flu shot to the nuts

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