You can't do that with Pihole as the ads come from the same domains, and basically need a browser extension or an app with a built in equivalent.
If you're in the UK though, it does block the ads on All4 which was a nice surprise. It even works for the TV app.
It was, and then it wasn't as the admin had to enable Cloudflare DDOS protection during the Reddit surge. This broke federation, but it's back off now and Kbin's back in the fold.
I haven't touched Reddit since discovering kbin and Lemmy. I'm sure I'll end up using it inow and again when searching for stuff, but otherwise good riddance.
I just switched from Pop!_OS to openSUSE, but not through any fault of Pop. I really liked it in fact, and it was great to have a distro to show me out of the box what was possible on other distros after a bit of configuration. It's certainly tempting me to get a System76 laptop.