I run Arch (btw). What are you looking to use? If you’re comfortable with a terminal or willing to read a lot of documentation to get there (it’s all fairly approachable and well laid out) and rolling release suits your needs, I definitely recommend Arch.
EDIT: whoops thought you were OP. recommendation still stands though
There really isn’t any manual setup required even on desktop Linux, as long as you have all your drivers installed. Valve has done a really good job making gaming on Linux super painless